The City-relics were crafted during the War of the Divine Child. The artifact known as the Eye of Proteus was first used by Sartan to create the Fissure within Mhaldor. The Eye was eventually stolen by the goddess Valunrana and given to Eris, the theft marking a turning point in the war. Through the powers of the Eye, the city patrons were able to intermingle their power and craft the different relics. The relics in turn birthed both a Guardian for their respective city and a race of creatures that were released into the wilds of Sapience. If a guardian should fall, their connected relic will drain of power and must be refilled through the essence of the creatures spawned from the other relics.
| City | Relic | Guardian | Creature |
| Ashtan | Well of Chaos | the Guardian of Chaos | unformed things of Chaos |
| Cyrene | Icerune Crater | Blu the dragon | mountain drakes |
| Eleusis | Cauldron of Infinity | the Guardian of Nature | flower maidens |
| Hashan | Fontis | dracolich | lamassu |
| Mhaldor | Fissure | Mhaldorus | abominations |
| Shallam | Daybreak's Mirror | kirin | faeries |